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Abstract Details
Ceramide Salvage, Gut Mucosal IgA Signaling, and Diet-Induced NASH
Hepatology. 2021 Jan 15. doi: 10.1002/hep.31707. Online ahead of print.
Scott A McHenry1, Nicholas O Davidson1
Author information
1From the Gastroenterology Division, Washington University School of Medicine, St Louis, MO, USA.
Abstract
Nonalcoholic fatty liver disease (NAFLD) may arise from genetic and/or environmental factors that modulate enterohepatic signaling through gut-derived enterokines, cytokines, bile acids, and microbial products (including sphingolipids) that in turn regulate hepatic metabolic pathways.(1)Alterations within the enterohepatic axis may induce multiple parallel hits and promote NAFLD progression to nonalcoholic steatohepatitis (NASH), for example, by impairing immunologic tolerance to lipid droplet accumulation.(2).