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Abstract Details
AGA Clinical Practice Update on Lifestyle Modification Using Diet and Exercise to Achieve Weight Loss in the Management of Nonalcoholic Fatty Liver Disease (NAFLD): Expert Review
Gastroenterology. 2020 Dec 8;S0016-5085(20)35538-4.doi: 10.1053/j.gastro.2020.11.051. Online ahead of print.
Zobair M Younossi1, Kathleen E Corey2, Joseph K Lim3
Author information
1Center for Liver Diseases and Department of Medicine, Inova Fairfax Medical Campus, Falls Church, VA, USA; Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, USA. Electronic address: zobair.younossi@inova.org.
2Liver Center, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
3Yale Liver Center and Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA.
Abstract
Nonalcoholic fatty liver disease. (NAFLD) is a leading etiology for chronic liver disease with global public health impact, affecting over 25% of the global population. NAFLD is associated with significant morbidity and mortality from cirrhosis, hepatocellular carcinoma (HCC), solid organ malignancies, diabetes mellitus, cardiovascular disease, and obstructive sleep apnea, resulting in significant healthcare resource utilization and decreased health-related quality of life. NAFLD cirrhosis is a leading indication for liver transplantation in the United States. Lifestyle modification to achieve weight loss remains a first line intervention in patients with NAFLD. Herein we summarize evidence-based interventions for lifestyle modification in the treatment of NAFLD and provide Best Practice Advice (BPA) statements to address key issues in clinical management.