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Abstract Details
Hepatitis C: Does Successful Treatment Alter the Natural History and Quality of Life?
Gastroenterol Clin North Am. 2020 Jun;49(2):301-314.doi: 10.1016/j.gtc.2020.01.007. Epub 2020 Mar 29.
Humberto C Gonzalez1, Stuart C Gordon2
Author information
1Department of Gastroenterology and Hepatology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA; Wayne State University School of Medicine, 42 W Warren Ave, Detroit, MI 48202, USA.
2Department of Gastroenterology and Hepatology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA; Wayne State University School of Medicine, 42 W Warren Ave, Detroit, MI 48202, USA. Electronic address: sgordon3@hfhs.org.
Abstract
The cure of chronic hepatitis C infection has a major impact on the morbidity and mortality of infected patients. It is now clear that sustained virologic response improves overall survival and significantly reduces the risk of liver failure, fibrosis progression, need of liver transplantation, and incidence of hepatocellular carcinoma. Moreover, hepatitis C eradication improves a broad range of extrahepatic manifestations, such as dermatologic, neoplastic, cardiovascular, and endocrine, and improves quality of life.