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Abstract Details
Care Quality and Outcomes Among U.S. Veterans With Chronic Hepatitis B in the Hepatitis C Direct Acting Antiviral Era
Viral Hepat. 2020 Jun 2. doi: 10.1111/jvh.13340. Online ahead of print.
David E Kaplan12, Elina Medvedeva2, Marina Serper132
Author information
2Center for Health Equity Research and Promotion, Philadelphia VA Medical Center, Philadelphia, PA, United States.
3Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, United States.
Abstract
Adherence to guideline-recommended hepatitis B virus (HBV) care is suboptimal. We hypothesized that national hepatitis C eradication efforts during the era from 2015-2017 would improve the quality of care for cHBV given increased recognition and specialty referrals for liver disease. The study described herein is a retrospective cohort study of veterans with at least one positive HBsAg (HBsAg+) result from January 1, 2003 to December 31st, 2017 using the VA Corporate Data Warehouse (CDW) analyzed by era (2003-2004, 2005-2009, 2010-2014, 2015-2017). Relevant covariates such as HCV coinfection, demographics, cirrhosis, and baseline laboratory testing were obtained through previously validated approaches. We evaluated completion of process measures within 2 years of the index HBsAg+ result: specialty care referral; testing of ALT, HBV-DNA, HBeAg, anti-HBe; testing for coinfection and/or vaccination for HAV, HCV, HDV, and HIV; and hepatocellular carcinoma (HCC) surveillance among those meeting criteria. We also measured use of antiviral therapy in appropriate candidates (ALT ≥ 2 x ULN, HBVDNA ≥ 2000 IU/ml). Of the 16,673 individuals with HBsAg+ test results, 9,521 were confirmed as chronic HBV. Era-related (Era 3: 2010-2014 versus Era 4: 2015-2017) increases in guideline-recommended process measures included: outpatient visits with GI/ID specialists (78% to 89%), HBV-DNA testing (73% to 79%), HDV testing (27% to 35%), appropriate HBV antiviral utilization (55% to 70%), and HCC surveillance (40% to 43%); all p<.0001. In the subset of HBV/HCV coinfected patients, HCV DAA therapy was associated with a trend towards improved overall survival. In conclusion, the overall quality of care for HBV has significantly improved in the era of widespread HCV DAA therapy in an integrated health system possibly due to increased recognition and referral for liver disease.