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Abstract Details
Genetic Determinants of Cirrhosis and Hepatocellular Carcinoma Due to Fatty Liver Disease: What's the Score?
Hepatology. 2020 Jun 7. doi: 10.1002/hep.31413. Online ahead of print.
Ruth M Pfeiffer1, Yaron Rotman2, Thomas R O'Brien1
Author information
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
2Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Abstract
Fatty liver disease (FLD), either alcoholic or nonalcoholic, is the most common liver disorder in developed countries. In the United States, alcohol-associated liver disease (ALD) has an estimated prevalence of 2% and is the leading indication for liver transplant listing. Nonalcoholic fatty liver disease (NAFLD), which is associated with obesity and insulin resistance, affects 25% to 30% of adults worldwide. ALD and NAFLD are leading causes of cirrhosis and hepatocellular carcinoma (HCC), and despite having different etiologies, these diseases share histological features and genetic risk factors, suggesting common underlying biological pathways.