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Abstract Details
Hepatitis B virus gene mutations and hepatocarcinogenesis
Liang T, Chen EQ, Tang H. Asian Pac J Cancer Prev. 2013;14(8):4509-13.
Author information
Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China E-mail : htang6198@hotmail.com.
Abstract
Chronic hepatitis B virus (HBV) infection has long been the most common cause of hepatocellular carcinoma (HCC). However, some aspects of the pathogenesis of HBV infection and genesis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) are still inconclusive. An increasing number of published studies indicate that hepatitis B virus mutations are associated with risk of HCC. These variations include, in particular, mutations in ORF S,C,X gene regions. This mini-review summarizes results of clinical studies and molecular mechanisms on the possible relations of HBV mutations with the development of hepatocellular carcinoma.