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Abstract Details
Hepatitis B virus-induced hepatocellular carcinoma
Xu C, Zhou W, Wang Y, Qiao L. Cancer Lett. 2013 Aug 25. pii: S0304-3835(13)00610-1. doi: 10.1016/j.canlet.2013.08.035. [Epub ahead of print]
Source
Institute for Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Abstract
Many factors are considered to contribute to hepatitis B virus (HBV) associated hepatocellular carcinoma (HCC), including products of HBV, HBV integration and mutation, and host susceptibility. HBV X protein (HBx) can interfere with several signal pathways that associated with cell proliferation and apoptosis, and the impact of HBx C-terminal truncation in the development of HCC has been implicated. Recent studies by advanced sequencing technologies have revealed recurrent HBV DNA integration sites in hepatoma cells and susceptible genes/SNPs play an important role in the pathogenesis of liver cancer. Epigenetic changes, immune and inflammatory factors are also important contributing factors for liver cancer. This mini-review provides an overview on the recent development of HBV induced HCC.