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Abstract Details
Results of treatment of chronic hepatitis B with pegylated interferon
Viganò M, Mangia G, Lampertico P. Clin Liver Dis. 2013 Aug;17(3):425-43. doi: 10.1016/j.cld.2013.05.004. Epub 2013 Jul 3.
Source
Hepatology Division, Ospedale San Giuseppe, Università degli Studi di Milano, Via San Vittore 12, Milano 20123, Italy.
Abstract
Persistent viral eradication or suppression through a defined course of Pegylated-interferon (PegIFN) or the administration of a long-term potent nucleot(s)ide analogues (NUCs) can impact positively the natural course of HBV infection by preventing disease progression. Despite the higher rates of off-therapy response achieved with PegIFN compared with NUC, its benefits are restricted to a subgroup of patients only. To increase the rates of patients who may benefit from PegIFN treatment, minimizing the adverse events, careful patient selections based on baseline features and on treatment HBsAg kinetics for individual treatment optimization are required.