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Abstract Details
HBsAg quantification to predict natural history and treatment outcome in chronic hepatitis B patients
Martinot-Peignoux M, Asselah T, Marcellin P. Clin Liver Dis. 2013 Aug;17(3):399-412. doi: 10.1016/j.cld.2013.05.006. Epub 2013 Jun 27.
Source
INSERM U773/CRB3, Université Paris-Diderot, Paris, France. michelle.martinot@inserm.fr
Abstract
There is a growing interest in serum HBsAg quantification (qHbsAg). HBsAg titers are negatively correlated with liver fibrosis in HBeAg(+) patients. In HBeAg(-) HBsAg level <1000 IU/ml and HBV-DNA titer <2000 IU/ml accurately identify inactive carriers. During PEG-IFN treatment qHBsAg identifies patients with no benefit from therapy at week 12, allowing stopping or switched- "week 12 stopping rule". During nucleos(t)ide analogues the role of qHBsAg need to be clarified. In clinical practice qHBsAg is a simple and reproducible tool that may be used in association with HBV-DNA to classify patients during the natural history of HBV and to monitor therapy.