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Abstract Details
Macrophage Nourishment in NASH: A Novel Role for Ketone Bodies
Torok NJ1. Hepatology. 2019 May 20. doi: 10.1002/hep.30777. [Epub ahead of print]
Author information
1 Gastroenterology and Hepatology, Stanford University and VA, Palo Alto, CA.
Abstract
Since the seminal paper by Krebs in 1966 on the regulation of hepatic ketone body production and release (1), there has been a recent resurrection of interest relating to ketogenesis and its role in tissue homeostasis. In physiological states, the liver relies on glucose for its primary fuel, while the production and export of ketone bodies provides other organs with nutrients needed to meet higher energy requirements. During increased calorie intake, hepatocytes are exposed to enhanced lipid influx, and they deal with this by increasing the tricarboxylic acid (TCA) cycle load but at the expense of enhanced redox stress.