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Abstract Details
Hepatitis B Virus and HIV Coinfection: Fibrosis, Fat, and Future Directions
Kim AY1. Am J Gastroenterol. 2019 Apr 12. doi: 10.14309/ajg.0000000000000231. [Epub ahead of print]
Author information
1 Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Abstract
HIV and hepatitis B virus (HBV) share routes of transmission, and coinfection is associated with higher levels of HBV DNA, accelerated fibrosis progression, and increased liver-related events compared with those with HBV alone. The full spectrum of hepatic histology has not been recently addressed, in part because of the decreasing use of liver biopsy in clinical practice. The current study provides a modern "snapshot" of biopsy data from 114 HIV/HBV coinfected individuals, elucidating the degree of liver fibrosis years into the effective antiretroviral era and also revealing that hepatic steatosis was a frequent finding.