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Abstract Details
Hepatitis B infection increases the risk of non-Hodgkin lymphoma: A meta-analysis of observational studies
Dalia S, Chavez J, Castillo JJ, Sokol L. Leuk Res. 2013 Sep;37(9):1107-15. doi: 10.1016/j.leukres.2013.06.007. Epub 2013 Jun 26.
Source
H. Lee Moffitt Cancer and Research Institute, Division of Hematological Malignancies and the University of South Florida, Tampa, FL, USA. Electronic address: sdalia@gmail.com.
Abstract
Hepatitis B virus (HBV) infection is a major public health problem and the association between HBV infection and non-Hodgkin lymphoma (NHL) is unclear. The primary aim of our study was to evaluate the association between HBV infection assessed by a positive hepatitis B surface antigen (HBsAg) and the incidence of NHL and subtypes using a meta-analysis of epidemiological studies. The random effects model was used to calculate the outcome. Our search yielded 17 case-control and 5 cohort studies, including over 40,000 NHL cases. HBV infected individuals had an OR of 2.24 (95% CI 1.80-2.78; p≤0.001) of developing NHL. In high HBV prevalent countries, there were increased odds of diffuse large B-cell lymphoma and a trend toward increased odds of developing follicular and T-cell lymphoma. Future research is needed to better understand the biological mechanisms responsible for lymphomagenesis in patients with HBV infection