The summaries are free for public
use. The Chronic Liver Disease
Foundation will continue to add and
archive summaries of articles deemed
relevant to CLDF by the Board of
Trustees and its Advisors.
Abstract Details
Late-onset Stevens-Johnson syndrome due to nivolumab use for hepatocellular carcinoma
Dasanu CA1,2. J Oncol Pharm Pract. 2019 Feb 19:1078155219830166. doi: 10.1177/1078155219830166. [Epub ahead of print]
Author information
1 Lucy Curci Cancer Center, Eisenhower Medical Center, Rancho Mirage, CA, USA.
2 UC San Diego, San Diego, CA, USA.
Abstract
Nivolumab is a fully human immunoglobulin G4 immune checkpoint inhibitor antibody approved for use in the treatment of several malignancies. Severe side effects such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) have only extremely rarely been reported with this drug. We present herein a patient who developed SJS after 16 weeks of therapy with nivolumab. A week prior to this event, he developed a pruriginous papulo-erythematous rash. Prompt recognition of this phenomenon, immune checkpoint inhibitor discontinuation and steroid therapy are necessary steps in order to avoid dismal outcomes.