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Abstract Details
Tie-ing up angiogenesis to treat NASH
Davidson NO1. Hepatology. 2018 Oct 16. doi: 10.1002/hep.30318. [Epub ahead of print]
Author information
1
Department of Medicine, Washington University School of Medicine, Saint Louis, MO, 63110.
Abstract
There is increasing interest in the role of angiogenesis in fibrogenic signaling, via generation of proangiogenic mediators that perpetuate injury and promote fibrosis [reviewed in (1)]. This is a timely development in understanding the underlying mechanisms and pathways that promote progression of nonalcoholic fatty liver disease (NAFLD) to steatohepatitis (NASH) with fibrosis and hepatocellular cancer (HCC), given the global impact of these diseases (2).