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Abstract Details
Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe?
Grunhut J1, Wang W1, Aykut B1, Gakhal I1, Torres-Hernandez A1, Miller G1,2. Eur Med J Hepatol. 2018;6(1):100-109. Epub 2018 May 31.
Author information
1
S.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York City, New York, USA.
2
Department of Cell Biology, New York University School of Medicine, New York City, New York, USA.
Abstract
Nonalcoholic steatohepatitis (NASH) is a subtype of nonalcoholic fatty liver disease that is characterised by steatosis, chronic inflammation, and hepatocellular injury with or without fibrosis. The role and activation of macrophages in the pathogenesis of NASH is complex and is being studied for possible therapeutic options to help the millions of people diagnosed with the disease. The purpose of this review is to discuss the pathogenesis of NASH through the activation and role of Kupffer cells and other macrophages in causing inflammation and progression of NASH. Furthermore, this review aims to outline some of the current therapeutic options targeting the pathogenesis of NASH.