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Abstract Details
IL21 and IL21R polymorphisms and their interactive effects on serum IL-21 and IgE levels in patients with chronic hepatitis B virus infection
Li N, Zhu Q, Li Z, Han Q, Chen J, Lv Y, Wang Y, Zeng X, Chen Y, Yang C, Liu Z. Hum Immunol. 2013 Jan 24. pii: S0198-8859(13)00016-5. doi: 10.1016/j.humimm.2013.01.005. [Epub ahead of print]
Source
Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi' an 710061, Shaanxi Province, China.
Abstract
Interleukin (IL)-21 may affect both T-cell and B-cell responses and was suggested to be involved in response to HBV infection. This study explored IL21rs907715 and rs2221903 and IL21R T-83C and rs3093301 polymorphisms and serum IL-21 and IgE levels in 395 patients with chronic HBV infection, 75 HBV infection resolvers and 174 healthy controls. IL21R T-83C was not polymorphic in the study populations. IL21 rs2221903 AG was less frequent in HBV patients than in resolvers (p<0.001, OR=0.364, 95% CI=0.211-0.629) or in controls (p=0.017, OR=0.589, 95% CI=0.381-0.911). IL21R rs3093301 TT was more frequent in HBV patients than in controls [p value after Bonferroni correction (p(c))=0.022, OR=1.908, 95% CI=1.158-3.142] and more frequent in resolvers than in controls (p(c)=0.010, OR=2.965, 95% CI 1.375-6.392). The carriage of IL21 rs2221903 AG/IL21R rs3093301 CT+IL21 rs2221903 AG/IL21R rs3093301 TT was less frequent in patients than in resolvers (p(c)=0.007, OR=0.236, 95% CI=0.096-0.579) and more frequent in resolvers than in controls (p(c)=0.014, OR=4.354, 95% CI=1.660-11.420). IL21 rs2221903 was, by interaction with IL21R rs3093301, associated with serum IL-21 and IgE levels in HBV patients. It is suggested that IL21 rs2221903 and IL21R rs3093301 polymorphisms may, independently or interactively, affect the susceptibility to and/or persistence of HBV infection potentially through altering IL-21 and IgE production.