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Abstract Details
Hepatitis C Genotype 3 Infection: Pathogenesis and Treatment Horizons
Author information
1
Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, 676 North St Clair, 19th Floor, Chicago, IL 60611, USA. Electronic address: HMADDUR@nm.org.
2
Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, 676 North St Clair, 19th Floor, Chicago, IL 60611, USA.
Abstract
Genotype 3 hepatitis C infection is the second most common genotype worldwide and accounts for most infections in Southeast Asia. It is a particularly ominous genotype because it has been linked to increased mortality, specifically increased late-stage liver events, accelerated development of hepatic fibrosis, and an increased risk of hepatocellular carcinoma. As new treatment regimens for hepatitis C have been emerging, treatment of genotype 3 often requires longer treatment duration with decreased response rates as compared with other genotypes.