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Abstract Details
Treatment of Hepatitis C in HIV-Infected Patients: Moving Towards an Era of All Oral Regimens
Chen TY1, Jain MK1. AIDS Patient Care STDS. 2015 Jun;29(6):329-37. doi: 10.1089/apc.2014.0247.
Author information
1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Abstract
Hepatitis C (HCV)-related liver disease has become one of the leading causes of death in HIV patients. With the development of new direct-acting antivirals for HCV, treatment regimens have become shorter, more effective, and easier to tolerate without interferon. However, cost may be a significant impediment to the widespread use of these newer agents in both resource-rich and resource-poor settings. In HIV patients, treatment for HCV is not always as straightforward compared with HCV monoinfected patients due to potential drug-drug interactions. In this article, we will examine by genotypes the FDA approved direct-acting antivirals, as well as those in clinical trials that will soon be FDA-approved focusing on data in HCV/HIV co-infection. Preferred agents for HCV treatment and potential drug-drug interactions with antiretroviral therapy (ART) will be highlighted.