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Abstract Details
Association of IL28B polymorphisms with virological response to peginterferon and ribavirin therapy in children and adolescents with chronic hepatitis C
Tajiri H, Tanaka Y, Takano T, Suzuki M, Abukawa D, Miyoshi Y, Shimizu T, Brooks S. Hepatol Res. 2013 Jul 11. doi: 10.1111/hepr.12206. [Epub ahead of print]
Source
Department of Pediatrics, Osaka General Medical Center.
Abstract
AIMS:
To find baseline predictive factors of response to therapy with pegylated interferon and ribavirin (PEG-IFN/RBV therapy) in children and adolescents with chronic hepatitis C.
METHODS:
IL28B genotype and mutations in the core of HCV were analyzed in 30 patients treated with PEG-IFN/RBV for HCV infection. The initial rate of decrease in the viral load was assessed during the first two weeks of treatment.
RESULTS:
IL28B major allele was seen more frequently in patients with sustained virologic response (SVR) than in non-SVR patients (P<0.001). There was no difference between these two groups in frequency of Core 70 mutation. Among patients with genotype-1, SVR was achieved in more patients (P=0.007) in the IL28B major allele group than in those in the minor allele group. The early decrements in the viral load (log/two weeks) were 3.80 ± 0.86 in the genotype-2 major allele group, 1.82±0.84 in the genotype-1 major allele group, and 0.41±0.33 in the genotype-1 minor allele group.
CONCLUSIONS:
Among pediatric patients with HCV infection the effectiveness of PEG-IFN/RBV therapy may be lower in the group with genotype-1 IL28B minor alleles than in other groups with IL28B major allele. Treatment strategy should be carefully implemented in patients with IL28B unfavorable type.