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Abstract Details
Rapid hepatitis C virus divergence among chronically infected individuals
Cruz-Rivera M, Carpio-Pedroza JC, Escobar-Gutiérrez A, Lozano D, Vergara-Castaneda A, Rivera-Osorio P, Martinez-Guarneros A, Chacon CA, Fonseca-Coronado S, Vaughan G. J Clin Microbiol. 2012 Dec 5. [Epub ahead of print]
Source
Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Abstract
Here, we analyze the viral divergence among HCV chronic cases infected with genotype 1. The intrahost viral evolution was assessed by deep sequencing using the 454 Genome Sequencer platform. The results showed a rapid nucleotide sequence divergence. This notorious short-term viral evolution is of the utmost importance for the study of HCV transmission because direct links between related samples were virtually lost. Thus, rapid divergence of HCV significantly affect genetic relatedness studies and outbreak investigations.