Author information
1Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.
2Genetics of Complex Phenotypes Research Unit, Bambino Gesù Children's Hospital, IRCCS, Viale S. Paolo, 15, Rome 00146, Italy.
3Genetics of Complex Phenotypes Research Unit, Bambino Gesù Children's Hospital, IRCCS, Viale S. Paolo, 15, Rome 00146, Italy. Electronic address: anna.alisi@opbg.net.
Abstract
Metabolic-associated fatty liver disease (MAFLD), the term proposed to substitute nonalcoholic fatty liver disease, comprises not only liver features but also potentially associated metabolic dysfunctions. Since experimental studies in mice and retrospective clinical studies in humans investigated the association between nonalcoholic fatty liver disease during pregnancy and the adverse clinical outcomes in mothers and offspring, it is plausible that MAFLD may cause similar or worse effects on mother and the offspring. Only a few studies have investigated the possible association of maternal MAFLD with more severe pregnancy-related complications. This article provides an overview of the evidence for this dangerous liaison.