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Abstract Details
Metabolic Syndrome and Its Association with Nonalcoholic Steatohepatitis
Clin Liver Dis. 2023 May;27(2):187-210. doi: 10.1016/j.cld.2023.01.002.Epub 2023 Feb 26.
1Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: Fbril@uab.edu.
2Division of Gastroenterology, Hepatology and Nutrition, School of Medicine Internal Medicine, Virginia Commonwealth University.
3Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, FL, USA.
Abstract
The relationship between insulin resistance, metabolic syndrome (MetS), and nonalcoholic fatty liver disease (NAFLD) is complicated. Although insulin resistance is almost universal in people with NAFLD and MetS, NAFLD may be present without features of MetS and vice versa. While NAFLD has a strong correlation with cardiometabolic risk factors, these are not intrinsic components of this condition. Taken together, our knowledge gaps call for caution regarding the common assertion that NAFLD is the hepatic manifestation of the MetS, and for defining NAFLD in broad terms as a "metabolic dysfunction" based on a diverse and poorly understood constellation of cardiometabolic features.