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Abstract Details
Genetic Markers Predisposing to Nonalcoholic Steatohepatitis
Clin Liver Dis. 2023 May;27(2):333-352. doi: 10.1016/j.cld.2023.01.006.Epub 2023 Mar 8.
1Liver Institute Northwest, 3216 Northeast 45th Place Suite 212, Seattle, WA 98105, USA.
2Department of Internal Medicine, UCSF Fresno, 155 North Fresno Street, Fresno, CA 93722, USA.
3Liver Institute Northwest, 3216 Northeast 45th Place Suite 212, Seattle, WA 98105, USA; Elson S. Floyd College of Medicine, Washington State University, WA, USA. Electronic address: kkowdley@liverinstitutenw.org.
Abstract
The growing prevalence of nonalcoholic fatty liver disease (NAFLD) has sparked interest in understanding genetics and epigenetics associated with the development and progression of the disease. A better understanding of the genetic factors related to progression will be beneficial in the risk stratification of patients. These genetic markers can also serve as potential therapeutic targets in the future. In this review, we focus on the genetic markers associated with the progression and severity of NAFLD.