The summaries are free for public
use. The Chronic Liver Disease
Foundation will continue to add and
archive summaries of articles deemed
relevant to CLDF by the Board of
Trustees and its Advisors.
Abstract Details
Combined Loco-Regional and Systemic Treatment Strategies for Hepatocellular Carcinoma: From Basics to New Developments
Cardiovasc Intervent Radiol. 2022 Dec 7. doi: 10.1007/s00270-022-03327-4.Online ahead of print.
1Department of Radiology, IRCCS San Raffaele Hospital, Via Olgettina 60, 20132, Milan, Italy. dellacorte.angelo@hsr.it.
2Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy. dellacorte.angelo@hsr.it.
3Vita-Salute San Raffaele University, 20132, Milan, Italy. dellacorte.angelo@hsr.it.
4Unit of Oncology, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
5Department of Radiology, IRCCS San Raffaele Hospital, Via Olgettina 60, 20132, Milan, Italy.
6Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
7Vita-Salute San Raffaele University, 20132, Milan, Italy.
8Hepatobiliary Surgery Division, IRCCS San Raffaele Hospital, 20132, Milan, Italy.
Abstract
Recent advances in systemic therapeutic options have led to improved survival in patients with advanced hepatocellular carcinoma. In order to optimize patient outcomes across different disease stages, attempts are being made at exploiting combinations of loco-regional treatments and systemic therapeutic regimens. The possibilities of a beneficial synergistic effect are strongly supported by biological evidence of changes in tumor microenvironment and systemic immunity. With the advent of newer interventional technologies and newer biological and immunological drugs, these possibilities keep on gaining interest and expectations, yet many questions remain unanswered as to how to best manipulate and combine the two therapeutic approaches.This review aims at providing a general overview of biological foundations, preliminary clinical applications, critical issues and future directions of this constantly growing field.