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Abstract Details
The role of oxidized lipid species in insulin resistance and NASH in children
Front Endocrinol (Lausanne). 2022 Oct 3;13:1019204.doi: 10.3389/fendo.2022.1019204. eCollection 2022.
1Department of Pediatrics, Kansas Medical Center, Kansas City, KS, United States.
2Department of Medicine and Health Sciences, "V.Tiberio" University of Molise, Campobasso, Italy.
3Department of Pediatrics, Yale University School of Medicine, New Haven, CT, United States.
4Department of Pediatrics, University of California San Diego, La Jolla, CA, United States.
Abstract
During the last two decades, nonalcoholic fatty liver disease (NAFLD) has emerged as the most common hepatic disease in pediatrics, mainly owing to the rising prevalence of pediatric obesity. Epidemiological studies have shown that the progressive increase in NAFLD prevalence is associated not only with obesity but also with changes in dietary habits experienced by all age groups, characterized by the increased intake of added sugars and certain fatty acids. In this review article, we focus on the effect of oxidized fatty acids deriving from linoleic acid and arachidonic acid on the pathogenesis and progression of NAFLD in youth.