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Abstract Details
Hepatitis C virus (HCV) micro-elimination in the hospital setting: The results of the HCV Caserta hospital project
1Infectious Diseases Unit, AORN Sant'Anna e San Sebastiano, Caserta, Italy.
2Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Italy.
3Clinical Pathology, AORN Sant'Anna e San Sebastiano, Caserta, Italy.
4Direzione Sanitaria, AORN Sant'Anna e San Sebastiano, Caserta, Italy.
5Regione Campania, Naples, Italy.
6Infectious Diseases Unit, AORN Sant'Anna e San Sebastiano, Caserta, Italy; Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Italy.
7Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Italy. Electronic address: nicola.coppola@unicampania.it.
Abstract
Background: In the present study we evaluated the efficacy of an innovative model of HCV micro-elimination in a hospital setting in an area of high HCV prevalence.
Patients and metods: Between January and December 2019, a prospective, interventional study for a program of HCV case-finding and linkage-to-care was performed in S. Anna and S. Sebastiano hospital of Caserta, in Campania, a region in southern Italy. All adult patients who were admitted to the Caserta hospital in the study period and resulted positive for anti-HCV were included in the study. The outcomes evaluated were the number of subjects resulting HCV-RNA-positive, those linked-to-care and treated with a DAA and the subjects whose anti-HCV-status was unknown.
Results: In the study period, 14,396 subjects, admitted to the hospital for different reasons, were tested for anti-HCV: 529 (3.7%) subjects resulted positive for anti-HCV. Of the 529 anti-HCV-positive subjects, 10 died during hospitalization and 243 were already treated with a DAA. The remaining 276 subjects were contacted and agreed to be evaluated. Of these 276 subjects, 68 patients resulted HCV- RNA-negative and 194 HCV-RNA-positive and 180 of these were treated with a DAA according to the international guidelines.
Discussion: A simple, rapid, inexpensive model of HCV micro-elimination in the hospital setting allowed us to find anti-HCV-positive subjects with unknown anti-HCV status or not linked to a clinical center.