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Abstract Details
NAFLD-related hepatocellular carcinoma: The growing challenge
Hepatology. 2022 Apr 28. doi: 10.1002/hep.32542. Online ahead of print.
1Department of Internal Medicine, University of Texas Health Science Center, San Antonio, Texas, USA.
2South Texas Research Institute, Edinburg, Texas, USA.
3Radcliffe Department of Medicine, University of Oxford, UK.
Abstract
Hepatocellular carcinoma (HCC) is a common cause of cancer-related mortality and morbidity worldwide. With the obesity pandemic, non-alcoholic fatty liver disease (NAFLD) related HCC is contributing to the burden of disease exponentially. Genetic predisposition and clinical risk factors for NAFLD-related HCC have been identified. Cirrhosis is a well-known and major risk factor for NAFLD-related HCC. However, the occurrence of NAFLD-related HCC in patients without cirrhosis is increasingly recognized and poses a significant challenge regarding cancer surveillance. It is of paramount importance to develop optimal risk stratification scores and models to identify subsets of the population at high risk so they can be enrolled in surveillance programs. In this review, we will discuss the risks and prediction models for NAFLD-related HCC.