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Abstract Details
Drugs of Abuse and Their Impact on Viral Pathogenesis
Viruses. 2021 Nov 29;13(12):2387. doi: 10.3390/v13122387.
1Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0595, USA.
2Center for Addiction Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0595, USA.
Abstract
Commonly misused substances such as alcohol, cocaine, heroin, methamphetamine, and opioids suppress immune responses and may impact viral pathogenesis. In recent years, illicit use of opioids has fueled outbreaks of several viral pathogens, including the human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). This review focuses on the myriad of mechanisms by which drugs of abuse impact viral replication and disease progression. Virus-drug interactions can accelerate viral disease progression and lead to increased risk of virus transmission.