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Abstract Details
Incidence of malignancies among patients with chronic hepatitis B in US health care organizations, 2006-2018
J Infect Dis. 2022 Jan 17;jiac011. doi: 10.1093/infdis/jiac011. Online ahead of print.
Philip R Spradling1, Jian Xing1, Y Zhong1, Loralee B Rupp2, Anne C Moorman1, Mei Lu2, Eyasu H Teshale1, Mark A Schmidt3, Yihe G Daida4, Joseph A Boscarino5, Stuart C Gordon26, Chronic Hepatitis Cohort Study (CHeCS) Investigators
Author information
Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Henry Ford Health System, Detroit, MI, USA.
The Center for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.
The Center for Integrated Health Care Research, Kaiser Permanente Hawaii, Honolulu, HI, USA.
Department of Population Health Sciences, Geisinger Clinic, Danville, PA, USA.
Wayne State University School of Medicine, Detroit, MI, USA.
Abstract
Hepatitis B virus (HBV) infection causes hepatocellular carcinoma but its association with other cancers is not well established. We compared age-adjusted incidence of primary cancers among 5,773 HBV-infected persons with US cancer registries during 2006-2018. Compared with the US population, substantially higher incidence among HBV-infected persons was observed for hepatocellular carcinoma (Standardized rate ratio [SRR] 30.79), gastric (SRR 7.95), neuroendocrine (SRR 5.88), cholangiocarcinoma (SRR 4.62), and ovarian (SRR 3.72) cancers, and non-Hodgkin lymphoma (SRR 2.52). Clinicians should be aware of a heightened potential for certain non-hepatic malignancies among hepatitis B patients, as earlier diagnosis favors improved survival.