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Abstract Details
Lower rates of emergency visits and hospitalizations among chronic hepatitis C patients with sustained virological response to interferon-free direct-acting antiviral therapy (2014-2018)
Clin Infect Dis. 2022 Feb 11;ciac124. doi: 10.1093/cid/ciac124. Online ahead of print.
Stuart C Gordon1, Eyasu H Teshale2, Philip R Spradling2, Anne C Moorman2, Joseph A Boscarino3, Mark A Schmidt4, Yihe G Daida5, Loralee B Rupp6, Sheri Trudeau7, Jiaqi Zhang7, Mei Lu7, CHeCS Investigators
Author information
1Department of Hepatology and Gastroenterology, Henry Ford Health System; and Wayne State University School of Medicine, Detroit MI.
2Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
3Department of Population Health Sciences, Geisinger Clinic, Danville PA.
4Center for Health Research, Kaiser Permanente Northwest, Portland, OR.
5Center for Integrated Health Care Research, Kaiser Permanente Hawaii, Honolulu, HI.
6Center for Health Policy and Health Systems Research, Henry Ford Health System, Detroit MI.
7Department of Public Health Sciences, Henry Ford Health System, Detroit MI.
Abstract
We compared rates of emergency department (ED) visits and hospitalizations between HCV patients who achieved sustained virological response (SVR) after direct-acting antiviral (DAA) therapy (cases) to matched controls. Among 3049 pairs, cases demonstrated lower rates of liver-related ED visits (P=.01) than controls; all-cause and liver-related hospitalization rates and hospitalized days were also lower in cases (P<.0001).