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Abstract Details
Circulating Pregenomic Hepatitis B Virus RNA Is Primarily Full-length in Chronic Hepatitis B Patients Undergoing Nucleos(t)ide Analogue Therapy
Clin Infect Dis. 2021 Jun 1;72(11):2029-2031. doi: 10.1093/cid/ciaa1015.
Mark Anderson1, Jeffery Gersch1, Ka-Cheung Luk1, George Dawson1, Ivana Carey2, Kosh Agarwal3, Pir Shah4, Geoffrey Dusheiko3, Daryl Lau4, Gavin Cloherty1
Author information
1Abbott Laboratories, Infectious Disease Core Diagnostics Department, Abbott Diagnostics Division, Abbott Park, Illinois, USA.
2King's College, Department of Infectious Diseases, London, United Kingdom.
3Institute of Liver Studies, King's College Hospital, London, United Kingdom.
4Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Abstract
Hepatitis B virus RNA is detectable in the serum of infected patients; however, the RNA species has been questioned. We tested 1827 specimens using a quantitative dual-target quantitative polymerase chain reaction assay and determined that full-length pregenomic RNA is the primary source. These results clarify the major identity of circulating HBV RNA species.