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Abstract Details
Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis: A Proof of Concept Study
Clin Gastroenterol Hepatol. 2021 Aug;19(8):1723-1725. doi: 10.1016/j.cgh.2020.08.063.Epub 2020 Aug 31.
Alexa Hughes1, Jessica Dahmus2, Gloriany Rivas2, Breianna Hummer2, Jeremy R Chen See3, Justin R Wright3, Regina Lamendella4, Kathryn H Schmitz5, Christopher Sciamanna6, Mack Ruffin7, Andrew D Patterson8, Rohit Loomba9, Jonathan G Stine10
Author information
1Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania.
2Division of Gastroenterology and Hepatology, Department of Medicine, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania.
3Wright Laboratories, Juniata, Pennsylvania.
4Department of Biology, Juniata College, Juniata, Pennsylvania.
5Department of Public Health Sciences, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania; Department of Kinesiology, Penn State College of Health and Human Medicine, Hershey, Pennsylvania; Department of Physical Medicine and Rehabilitation, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania; Cancer Institute, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania.
6Department of Public Health Sciences, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania; Cancer Institute, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania; Department of Medicine, The Pennsylvania State University- Milton S. Hershey Medical Center, Hershey, Pennsylvania.
7Division of Family and Community Medicine, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania.
8Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania.
9Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Diego, San Diego, California; NAFLD Research Center, University of California, San Diego, San Diego, California.
10Division of Gastroenterology and Hepatology, Department of Medicine, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania; Department of Public Health Sciences, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania; Cancer Institute, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania; Liver Center, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania. Electronic address: jstine@pennstatehealth.psu.edu.
Abstract
Nonalcoholic fatty liver disease is the leading cause of liver disease worldwide and can progress to nonalcoholic steatohepatitis (NASH) through physical inactivity and gut dysbiosis.1 Exercise training reverses gut dysbiosis in non-NASH persons with obesity and in NASH animal models.2,3Consequently, we conducted a proof-of-concept study investigating the effect of exercise training on gut dysbiosis in NASH patients.