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Abstract Details
Correlations between the time-intensity parameters of contrast-enhanced ultrasound and clinical prognosis of hepatocellular carcinoma
Yang YL, Yang RJ, Liu X, Liu J, Chao LJ, Duan YY. Clin Imaging. 2013 Mar-Apr;37(2):308-12. doi: 10.1016/j.clinimag.2012.06.002. Epub 2012 Jul 15.
Source
Department of Ultrasound, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, China. yilinyangcn@126.com
Abstract
PURPOSE:
The purpose of the study was to detect the correlation between the time-intensity parameters of contrast-enhanced ultrasound (CEUS) and the clinical prognosis of hepatocellular carcinoma (HCC).
METHODS:
A total of 73 HCC patients were analyzed with the time-intensity curve of CEUS. The expression of vascular endothelial factor (VEGF) and CD34 in different differentiation-staged HCC specimens was observed using immunohistochemistry.
RESULTS:
A positive correlation was found between the VEGF expression and microvessel density. The time-intensity parameters were not correlated with the HCC size.
CONCLUSIONS:
CEUS time-intensity parameters are inducive for assessing the prognosis of HCC with revealed intratumoral microvessel perfusion in different differentiation stages.