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Abstract Details
The Inflammatory Cytokine Profile Associated with Liver Damage is Broader and Stronger in Chronic Hepatitis B Patients Compared to Acute Hepatitis B Patients
Alexandra Johnson Valiente12, Kin Seng Liem23, Kathleen B Schwarz45, Philip Rosenthal6, Karen F Murray7, Douglas Mogul5, Jeffery Teckman8, Norberto Rodriguez-Baez9, Sarah Jane Schwarzenberg10, Jordan J Feld211, David K Wong2, Lia L Lewis-Ximenez12, Georg Lauer13, Bettina E Hansen214, Simon C Ling1516, Harry L A Janssen211, Adam J Gehring1211
Author information
1Department of Immunology, University of Toronto, Ontario, Canada.
2Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario Canada.
3Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
4Division of Pediatric Gastroenterology, University of California San Diego, San Diego, California, USA.
5Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, USA.
6Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA.
7Seattle Children's Hospital, Seattle, Washington, USA.
8Department of Pediatrics, Saint Louis University, St. Louis, Missouri, USA.
9Department of Pediatrics, University of Texas Southwestern, Dallas, Texas, USA.
10Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
11Institute of Medical Science, University of Toronto, Ontario, Canada.
12Viral Hepatitis Laboratory, Oswaldo Cruz Institute, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
13Massachusetts General Hospital, Boston, Massachusetts, USA.
14Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
15Division of Gastroenterology, Hepatology & Nutrition, the Hospital for Sick Children, Toronto, Ontario, Canada.
16Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.
Abstract
Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to different types of liver damage across patients at different stages of disease. We measured 25 inflammatory markers in acute hepatitis B, chronic hepatitis B patients with HBeAg seroconversion and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL and TNF-α.