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Abstract Details
Donor-Transmitted Malignancy in a Liver Transplant Recipient: A Case Report and Review of Literature
Kim B, Woreta T, Chen PH, Limketkai B, Singer A, Dagher N, Cameron A, Lin MT, Kamel I, Gurakar A. Dig Dis Sci. 2012 Dec 16. [Epub ahead of print]
Source
Division of Gastroenterology and Hepatology, Section of Transplant Hepatology, School of Medicine, Johns Hopkins University, 600 N. Wolfe Street, Blalock 459, Baltimore, MD, 21287, USA, bkim53@jhmi.edu.
Abstract
Donor-transmitted malignancy is a rare complication of organ transplantation. This case illustrates a donor-transmitted adenocarcinoma in a patient 11 months after an orthotopic liver transplant for cryptogenic cirrhosis and hepatocellular carcinoma (HCC). Diagnosis of donor-transmitted malignancy may be challenging and can be confused with HCC recurrence. A timely diagnosis is crucial as a delay may limit treatment options. Biopsy of newly found liver lesions and the use of karyotypic and microsatellite analysis may be essential for diagnosis. Protocols should be in place to help recognize and limit the incidence of donor-transmitted malignancy.