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Loomba R1, Decaris M2, Li KW2,3, Shankaran M3, Mohammed H2,3, Matthews M2,3, Richards LM1, Nguyen P1, Rizo E1, Andrews B1, Soto R1, Angel T3, Suri V4, Kitrinos KM4, Barnes D4, Czerwieniec G4, Brendza K4, Subramanian GM4, Gaggar A4, Hellerstein MK2,3. Clin Infect Dis. 2018 Dec 24. doi: 10.1093/cid/ciy1100. [Epub ahead of print] |
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Author information
1
University of California San Diego, La Jolla, CA.
2
KineMed, Inc., Emeryville, CA.
3
University of California Berkeley, Berkeley, CA.
4
Gilead Sciences, Inc., Foster City, CA.
Abstract
In a pilot study, heavy water labeling was used to determine HBsAg turnover rates in chronic hepatitis B (CHB) patients. The mean (SD) half-life of HBsAg in blood was 6.7 (5.5) days which therefore reflects recent production in liver and supports strategies aimed at reducing HBsAg production in CHB patients.
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