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Abstract Details
Animal Fat Intake Is Associated with Albuminuria in Patients with Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome
Nutrients. 2021 May 4;13(5):1548. doi: 10.3390/nu13051548.
Manuela Abbate12, Catalina M Mascaró12, Sofía Montemayor12, María Barbería-Latasa3, Miguel Casares4, Cristina Gómez5, Lucia Ugarriza126, Silvia Tejada127, Itziar Abete78, María Ángeles Zulet78, Antoni Sureda127, J Alfredo Martínez789, Josep A Tur127
Author information
1Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain.
2Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.
3Department of Preventive Medicine and Public Health, University of Navarra, 31008 Pamplona, Spain.
4Radiodiagnostics Service, Red Asistencial Juaneda, 07011 Palma de Mallorca, Spain.
5Clinical Analysis Service, University Hospital Son Espases, 07120 Palma de Mallorca, Spain.
6Camp Redó Primary Health Care Centre, 07010 Palma de Mallorca, Spain.
7CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
8Department of Nutrition, Food Sciences and Physiology, Center for Nutrition Research, University of Navarra, IDISNA, 31008 Pamplona, Spain.
Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are associated with chronic kidney disease (CKD). Diet could play a predisposing role in the development of increased albuminuria in patients with NAFLD and MetS; however, published evidence is still limited. The aim of this cross-sectional analysis was to assess whether dietary fats are associated with changes in urinary albumin-to-creatinine ratio (UACR) in 146 patients aged 40-60-years with NAFLD and MetS. Dietary data were collected by food frequency questionnaire; UACR was measured in a single first morning void. Sources and types of dietary fats used in the analysis were total fat, fats from animal and vegetable sources, saturated, monounsaturated, polyunsaturated, and trans fats. One-way analysis of variance was performed to assess differences in dietary fats intakes across stages of UACR. The association between dietary fats and UACR was assessed by Pearson's correlation coefficient and multivariable linear regression. Patients with increased UACR showed a worse cardiometabolic profile and higher intakes of animal fat, as compared to patients with normal levels of albuminuria. Animal fat intake was associated with mean UACR, independent of potential covariates.