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Abstract Details
Update on cardiovascular risk in nonalcoholic fatty liver disease
Michael P Johnston1, Janisha Patel2, Christopher D Byrne34
Author information
1Department of Gastroenterology, Glasgow Royal Infirmary, Glasgow, Scotland.
2Department of Hepatology, University Hospital Southampton.
3Nutrition and Metabolism, Faculty of Medicine, University of Southampton.
4National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
Abstract
Purpose of review: To summarize recent evidence demonstrating increased cardiovascular disease (CVD) risk, and how CVD risk may be reduced, in patients with nonalcoholic fatty liver disease (NAFLD).
Recent findings: NAFLD is a multisystem disease, defined by a spectrum of liver fat-associated conditions extending from simple steatosis, to inflammation, fibrosis and cirrhosis. NAFLD not only increases the risk of liver morbidity and mortality but also increases the risk of CVD morbidity and mortality and is associated with recognized CVD risk factors such as hypertension, atherogenic dyslipidaemia, type 2 diabetes mellitus and chronic kidney disease. Evidence suggests that the liver fibrosis stage may be a strong CVD risk factor. Lifestyle measures (e.g. weight loss and increased physical activity) are effective in improving CVD risk factors. Hypoglycaemic agents, such as the peroxisome proliferator-activated receptor gamma agonist pioglitazone and the glucagon-like peptide-1 receptor agonist liraglutide, reduce cardiovascular risk and may improve liver histology. Statin and antihypertensive treatments are well tolerated and currently it is unclear whether novel antifibrotic drugs will reduce CVD risk.
Summary: Assessment and treatment of increased cardiovascular risk is important in patients with NAFLD. If not contra-indicated, pioglitazone or a glucagon-like peptide 1 agonist should be considered and may benefit both CVD risk and early liver disease.