Author information
1
Department of Public Health, National University, San Diego, CA.
2
Department of Biology, Texas State University, San Marcos, TX.
3
Department of Neurology, Institute of Human Behavior and Allied Science, New Delhi, India.
4
Department of Internal Medicine, University of Central Florida/HCA GME Consortium, North Florida Regional Medical Center, Gainesville, FL.
5
Department of Internal Medicine, Hurontario Medical Clinic, Mississauga, Ontario, Canada.
6
Department of Internal Medicine & Psychiatry, Berkeley Medical & Rehabilitation Center, Atlanta, GA.
7
Department of Medicine, Osmania Medical College, Hyderabad, India.
8
Department of Internal Medicine, Morehouse School of Medicine, Atlanta, GA.
9
Department of Internal Medicine, Gastroenterology, NYU School of Medicine/Bellevue Hospital Center, New York, NY.
10
Department of Internal Medicine, Gastroenterology, Joan C. Edward School of Medicine, Marshall University, Huntington, WV.
Abstract
OBJECTIVES:
The aim of this study was to assess the role of hepatitis B (HepB) infection in the causation of pancreatic cancer and the predictors of pancreatic cancer and mortality.
METHODS:
We identified pancreatic cancer patients 11 to 70 years of age from the 2013-2014 National Inpatient Sample. Pearson χ test and Student's t-test were used for categorical and continuous variables, respectively. We assessed the association of HepB and pancreatic cancer and the independent mortality predictors by multivariate analyses.
RESULTS:
Of 69,210 pancreatic cancer patients, 175 patients with a history of HepB and 69,035 patients without a history of HepB were identified. Compared with the pancreatic cancer-non-HepB group, the pancreatic cancer-HepB group consisted more of younger (mean, 60.4 [standard deviation, 7.4] years vs 68.2 [standard deviation, 12.1] years), male, black, and Asian patients with low household income and nonelective admissions. The odds of developing pancreatic cancer among the HepB patients were significantly higher (adjusted odds ratio, 1.24; 95% confidence interval, 1.056-1.449; P = 0.008). Black race, age ≥ 65 years, and male sex demonstrated greater odds of mortality.
CONCLUSIONS:
This study concluded up to a 24% increased likelihood of pancreatic cancer among the HepB patients. Blacks showed greater odds of pancreatic cancer and related mortality.