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Abstract Details
Paradigm Shift in Utilization of Livers from Hepatitis C-Viremic Donors into Hepatitis C Virus-Negative Patients
Clin Liver Dis. 2021 Feb;25(1):195-207. doi: 10.1016/j.cld.2020.08.009.Epub 2020 Nov 5.
Eric F Martin1
Author information
1Division of Digestive Health and Liver Disease, University of Miami Miller School of Medicine, 1120 Northwest 14th Street, Suite 1112, Miami, FL 33136, USA. Electronic address: efm10@miami.edu.
Abstract
Despite record-breaking numbers of liver transplants (LTs) performed in the United States in each of the last 7 years, many patients remain on the wait list as the demand for LT continues to exceed the supply of available donors. The emergence of highly effective and well-tolerated direct-acting antiviral therapy has transformed the clinical course and management of hepatitis C virus (HCV) in both the pretransplant and posttransplant setting. Historically, donor livers infected with HCV were either transplanted into patients already infected with HCV or discarded.