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Abstract Details
Hepatitis B and C among patients with hidradenitis suppurativa: a population-based study
Int J Dermatol. 2021 May 17. doi: 10.1111/ijd.15578. Online ahead of print.
Jeffrey M Cohen1, Khalaf K Kridin2, Lourdes M Perez-Chada3, Joseph F Merola34, Arnon D Cohen56
Author information
1Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.
2Department of Dermatology, Rambam Health Campus, Haifa, Israel.
3Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
4Divsion of Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
5Department of Quality Measures and Research, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel.
6Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Abstract
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory condition related to multiple systemic diseases and infections.
Methods: This retrospective cross-sectional study from 1999 to 2015 used the database of Clalit Health Services, the largest managed care organization in Israel, to explore the association between HS and hepatitis B and C. Sociodemographic and clinical information was compared using χ2 tests for sex and socioeconomic status and t-tests for age. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to compare the odds of hepatitis B and C in those with and without HS.
Results: In multivariate analysis controlling for sex, age as a continuous variable, Arab ancestry, and history of drug abuse, HS was associated with a 1.87-fold increased odds (95% CI 1.11-3.17, P = 0.019) of hepatitis B (HBV). HS was also associated with HCV in multivariate analysis controlling for sex, age per year, Arab ancestry, alcohol use, and drug use, with a 1.74-fold increased odds (95% CI 1.05-2.89, P = 0.032) of hepatitis C (HCV) among those with HS as compared to controls.
Conclusions: This study demonstrated an association between HS and both hepatitis B and hepatitis C.