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Abstract Details
Hepatitis C standards of care: A review of good practices since the advent of direct-acting antiviral therapy
Clin Res Hepatol Gastroenterol. 2021 Mar 15;45(2):101564.doi: 10.1016/j.clinre.2020.11.001. Online ahead of print.
Jeffrey V Lazarus1, Camila A Picchio2, Danielle Guy2, Soo Aleman3, Cary James4, Felice A Nava5, Anne Øvrehus6, Juan Turnes7, John W Ward8, Andy Ustianowski9
Author information
1Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain. Electronic address: Jeffrey.Lazarus@isglobal.org.
2Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain.
3Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
4World Hepatitis Alliance, London, United Kingdom.
5Penitentiary Medicine and Drug Abuse Units, Public Health Service, Padua, Italy.
6Department of Infectious Diseases, Odense University Hospital, Denmark.
7Department of Gastroenterology and Hepatology, C.H.U. Pontevedra and IIS Galicia Sur, Pontevedra, Spain.
8Coalition for Global Hepatitis Elimination (CGHE), Task Force for Global Health, Georgia, USA.
9Regional Infectious Diseases Unit, North Manchester General Hospital, United Kingdom; School of Medical Sciences, University of Manchester, United Kingdom.
Abstract
Significant steps must be taken to reduce the global incidence and prevalence of hepatitis C virus (HCV) and mortality from HCV infection to achieve the WHO goal of eliminating viral hepatitis as a public health threat by 2030. Proper epidemiological surveillance of the full continuum of care is essential for monitoring progress and identifying gaps that need to be addressed. The tools required for elimination have largely been established, and the issue at hand is more how they should best be implemented in different settings around the world. Documenting good practices allows for knowledge exchange to prevent transmission and improve health outcomes for people with HCV. This review found 13 well documented HCV good practices that have become the standard of care or that should become the standard of care as soon as possible. In 2013, highly effective direct-acting antiviral therapy became available, which has cure rates of over 95%. Together with this new therapy, evidence-based good practices can help countries eliminate viral hepatitis C.