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Abstract Details
Ten Thousand Points of Light - Heterogeneity Among the Stars of NASH Fibrosis
Hepatology. 2021 Mar 16.doi: 10.1002/hep.31807. Online ahead of print.
James Carter1, Shuang Wang1, Scott L Friedman1
Author information
1Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Abstract
Heterogeneity among hepatic stellate cells (HSCs), widely acknowledged as the 'stars' of hepatic fibrosis, has been hinted at for decades based on immunohistochemical methods. Now, more refined approaches, epitomized by the studies of Rosenthal et al. in this issue of Hepatology, have amplified this concept. Earlier investigators noted striking variability across the hepatic lobule in hallmark features of HSCs including vitamin A storage and dendritic arborization -- indications that not every HSC is alike.