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Abstract Details
Case-finding strategies in non-alcoholic fatty liver disease
JHEP Rep. 2020 Dec 5;3(2):100219. doi: 10.1016/j.jhepr.2020.100219.eCollection 2021 Apr.
Jerome Boursier12, Emmanuel A Tsochatzis34
Author information
1Service d'Hépato-Gastroentérologie et Oncologie Digestive, Centre Hospitalier Universitaire d'Angers, Angers, France.
2Laboratoire HIFIH, UPRES EA3859, SFR 4208, Université d'Angers, Angers, France.
3Sheila Sherlock Liver Centre, Royal Free Hospital, London, UK.
4UCL Institute for Liver and Digestive Health, Royal Free Campus, UCL, London, UK.
Abstract
Among the large population of patients with non-alcoholic fatty liver disease (NAFLD), identifying those with advanced disease remains challenging. Many patients are diagnosed late, following the development of liver-related complications, leading to poor clinical outcomes. Accumulating evidence suggests that using non-invasive tests for liver fibrosis in patients with metabolic risk factors improves the detection of patients in need of specialised management and is cost-effective. Because of the vast number of patients requiring evaluation, the active participation of general practitioners and physicians who manage patients with metabolic disorders, such as diabetologists, is crucial; this calls for the increased awareness of NAFLD beyond liver clinics. Non-invasive case-finding strategies will need to be further validated and generalised for upcoming drug therapies to have the required impact on the worldwide burden of NAFLD.