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Üçbilek, Enver (E);Y?ld?r?m, Abdullah Emre (AE);Ellik, Zeynep (Z);Turan, ?lker (?);Haktan?yan, Bü?ra (B);Orucu, Berk (B);Demir, Mehmet (M);Tozlu, Mukaddes (M);Y?lmaz, Nimet (N);Balaban, Yasmin (Y);Uyan?ko?lu, Ahmet (A);Akarsu, Mesut (M);Yolaçan, Ramazan (R);Sezgin, Orhan (O);Yalç?n, Kendal (K);Alada?, Murat (M);Toka, Bilal (B);Kefeli, Ay?e (A);Örmeci, Asl? (A);Yurçi, Alper (A);Fidan, Sami (S);Gençdal, Genco (G);Avc?o?lu, Ufuk (U);Çekin, Ayhan Hilmi (AH);Ebik, Berat (B);Karatay, Eylem (E);Aky?ld?z, Murat (M);Köksal, Ayd?n ?eref (A?);Özdo?an, Osman C (OC);Karasu, Zeki (Z);Idilman, Ramazan (R); |
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PMID: 39895062 https://pubmed.ncbi.nlm.nih.gov/39895062/
Abstract
BACKGROUND/AIMS: The aim of our study was to investigate the underlying causes behind the etiology of cirrhosis in Türkiye.
MATERIALS AND METHODS: The study was comprised of patients with cirrhosis located in the gastroenterology clinics of 28 centers in Türkiye between January 2000 and June 2021.
RESULTS: The study group consisted of 4953 cirrhotic patients (median age: 62.2 years, male / female: 58% / 42%). Among the patients, 39% of the patients were compensated, and 61% were decompensated. Furthermore, 47.5% had Child-Pugh class A, 38% had ChildPugh class B, and 14.5% had Child-Pugh class C. The most frequent complaints were abdominal bloating (28%). Ascites (54.2%) was the most common manifestation of decompensation. The median Child-Pugh and MELD-Na scores were 7.0 and 10.0, respectively. The most common cause of cirrhosis was chronic viral hepatitis (43%), followed by cryptogenic cirrhosis (CC) (19%), metabolic dysfunction-associated steatotic liver disease (MASLD)-related cirrhosis (13%), and alcohol-related cirrhosis (11%). Among the 950 patients with CC, 416 had metabolic abnormalities. If these 416 CC patients with metabolic abnormalities were categorized as having MASLDrelated cirrhosis, the proportion of MASLD-related cirrhosis increased to 21%. Thirteen percent of the patients were diagnosed with HCC, while 4% had extrahepatic malignancy. Female breast cancer (18%) and colorectal cancer (18%) were the most frequent extrahepatic malignancies.
CONCLUSION: Viral hepatitis remains the main cause of cirrhosis in Türkiye. However, its prevalence seems to be declining, whereas the prevalence of steatotic liver disease-related cirrhosis is increasing.
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